Request Now: Thorium-228 Request Form Now Open for the 2026 Supply Term

With the rising demand for thorium-228 (Th-228) feedstock to help the fight against cancer, the Department of Energy’s Office of Isotope R&D and Production (IRP) is working to secure the domestic supply to meet the growing demand. To address the needs of the community, IRP is now accepting requests for thorium-228 (Th-228) for the upcoming supply term of May 1, 2026 through April 30, 2027.

The deadline for application is January 30, 2026.

Interested research and industry customers are invited to submit a request using the updated online form. Please note that submitting a request should indicate a firm interest in purchasing the material.

The information collected will support IRP in evaluating requests, forecasting demand, and prioritizing allocations based on programmatic mission, end use and available supply.

About Thorium-228

Thorium-228 is a precursor for the production of lead-212 (Pb-212) and bismuth-212 (Bi-212), both used in targeted alpha therapy (TAT) for treating various cancers. Thorium-228 or its daughter isotope radium-224 can be loaded onto generators where it naturally decays. The resulting Pb-212 and Bi-212 are then eluted from the generators as needed to treat patients. Clinical trials in the United States and Europe are actively evaluating potential applications for breast, ovarian, bone, and prostate cancers.